Dr. Thea Sperelakis leaves Doctors Without Borders in the Congo when she learns that her internist father, Petros, has been injured by a hit and run driver and is in a coma at the Beaumont Clinic where he used to practice.  Her brother and sister, both physicians, offer no hope for his recovery and wish to withhold treatment.  Her other brother, Dimitri, who suffers from Asperger’s Syndrome, is a computer genius who creates a simulation of their father's accident.  He learns it was not a hit and run accident, but a deliberate attempt to kill Petros.

Thea is also afflicted with Asperger’s Syndrome, which is a form of autism. The Asperger’s has made her a superb doctor with an encyclopedic memory of medical papers, but it leaves her unable to judge the emotions of other people.  She disagrees with her siblings and constantly sits by her father's hospital bed, talking to him, asking "why" and "who."  Petros responds to her with eye contact, but when she brings in her siblings to see this, he does not respond.  He will only respond to Thea.

Her efforts to learn why Petros was targeted for death bring her face to face with a conspiracy involving medical fraud, not just in the records but in the very practice of medicine itself. She doesn't know who she can trust.  She must question the integrity of the clinic and its practices regardless of the danger to herself.

The Second Opinion is a well-written, powerful book.  It is fast-paced, filled with intrigue and suspense.  The plot's twists and turns leave have the reader questioning the integrity of the medical profession. There is a wealth of information about Asperger’s Syndrome.