Charlotte Hennesey, a geneticist, has the chance of a lifetime: examining the remains of Jesus. However, when the Vatican finds out, they make all attempts to not let that knowledge be known to the masses, especially after she injects herself with the DNA and is able to perform medical miracles. Charlotte gets kidnapped along with Amit Mizrachi, an archaeologist, and Julie LeRoux, Egyptologist, during attempts to find out if the remains were Jesus’s or not amidst the chaotic Middle East. The people who kidnapped them are plotting to rip the Holy Land apart.

The idea of Jesus’s remains being found and the DNA being identified is definitely interesting and relevant to today and today's technological discoveries. However, the concept of injecting the DNA into someone, especially one who is supposed to be as morally upright as Charlotte Hennesey, seems unrealistic. The additional plot of the kidnapping seems like a completely separate book from the DNA issues.

The character development is strong and well developed. Readers will be able to identify with each character and their struggle in trying to find out what is going on with the kidnapping and the turmoil of destroying the Holy Land using an old discovery. Overall, The Sacred Blood is a good novel with a great concept, mixed with some good characters.