Dr. Thea Speretake leaves Doctors Without Borders in the Congo when she learns that her internist father, Petros, has been injured by a hit-and-run driver and is in a coma at the Beaumont Clinic, where he used to practice. Her brother and sister, both physicians, offer no hope for his recovery and wish to withhold treatment. Thea’s other brother, Dimitri, who also suffers from Asperger Syndome, is a computer genius and recreates their father's accident. He learns that it was not a hit-and-run accident but a definite attempt to kill Petros.

Thea is also afflicted with the Asperger Syndrome, which is a form of autism. The Asperger Syndrome has made her a superb doctor with an encyclopedic memory of medical papers, but it leaves her with an inability to judge the emotions of other people. She disagrees with her siblings and constantly sits by her father's hospital bed, talking to him and asking "who?" and "why?" Petros responds to her with eye contact, but does not respond when she brings her siblings in to see this. He will only respond to Thea.

In her efforts to learn why Petros was the target for death, she is confronted with a conspiracy by the medical profession that involves fraud—not just records, but the practice of medicine itself. She doesn't know who she can trust. She must question the integrity of the clinic and its practices regardless of the danger to herself.

The Second Opinion is a well written, powerful book. It is fast-paced with intrigues and suspense. The plot is filled with twists and turns, giving the reader questions about the integrity of the medical profession. There is a wealth of information about Asperger Syndrome